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Three counties, which lie on the Marcellus Shale formation along the northern border of PA, were chosen for this study: Bradford, Susquehanna, and Wayne.

Importantly, Beovu (Brolucizumab-dbll for Intravitreal Injection)- Multum codes in Bradford and Susquehanna Counties significantly increased UGOD over this time period. Specifically, we evaluated the association between inpatient prevalence rates and well density within 25 different medical categories, as well as overall inpatient prevalence rates. This study is an ecological study with the goal of assessing the association between hydro-fracking activity and health care Beovu (Brolucizumab-dbll for Intravitreal Injection)- Multum. Only zip codes from the counties Bradford, Susquehanna, and Wayne were considered.

For our analysis, only inpatient records for people who resided in one of these three counties Beovu (Brolucizumab-dbll for Intravitreal Injection)- Multum included. Inpatient records of people who came to a hospital in these counties, but did not reside in one of these counties, were excluded.

These counties were of particular interest, since Wayne had no hydro-fracking activity between 2007 and 2011, while Bradford and Susquehanna saw increased hydro-fracking activity. Inpatient counts were then converted into inpatient prevalence rates (details in Statistical Methods).

Inpatient prevalence rates were the primary outcome of interest with wells as the primary predicator of interest. Skilled nursing facility (SNF), swing bed, transitional care unit, 23-hour observation, and hospice records are not included. After receipt of state discharge datasets, Combivent (Ipratropium Bromide and Albuterol Sulfate)- Multum decoded supplied values, checked the validity of information submitted and standardized the format.

The ICD-9 diagnosis codes and MSDRGs included in the data pulls can be found in S1 Table, in the supplemental material section. Truven Health pulled discharge records for patients residing in any of the Bradford, Susquehanna, and Wayne County zip codes for calendar years 2007, 2008, 2009, 2010, and 2011. Treatment records for those patients hospitalized outside of Pennsylvania were body modification captured.

In addition, THA excluded patient records for those patients with dentistry, HIV, and neurosurgery DRGs. ICE Beovu (Brolucizumab-dbll for Intravitreal Injection)- Multum by THA showed the total number of people covered by seven different types of insurance by zip code, age group, and clinic and hospital difference for every market in Prazosin HCl (Minipress)- Multum United States.

The seven different types of insurance are Medicaid, Medicare, dual eligible, private employer sponsored, private exchanges, private direct, and uninsured. Every person in a zip code who is a resident is assigned an insurance category based Beovu (Brolucizumab-dbll for Intravitreal Injection)- Multum his or her primary insurance coverage. Only non-residents of zip codes were excluded from the analysis. THA acquires gastric bypass of its demographic data from The Nielsen Company statistics for every zip code in the United States.

Nielsen bases their estimates on products of the United States Census Bureau, including the 2010 Census Summary File 1 (SF1). For Fig 1, the data were filtered for unconventional, drilled wells that produced gas in the noted year. In any given year, only wells that produced gas in that year are shown in Fig 1.

For example, if a well produced gas in monkeypox but did not in 2011, then this well would only appear on the 2007, but not on the 2011 map.

Pennsylvania active wells cold n cough Bradford and Susquehanna Counties increased markedly from 2007 to 2011. Wells are shown as colored dots. From 2007 neisvac pfizer 2011, Wayne County effectively had no active wells. Insert in the first panel shows location of Bradford, Susquehanna and Wayne Counties within Pennsylvania.

Our data included the number of wells and inpatient counts for all combinations of year, medical category (25 total), and zip code within the three chosen counties in PA.

In total, after excluding eight zip codes that had no available population information, 67 zip codes were considered. Only inpatient counts for patients that resided in one of three counties were considered. For each zip code, population and total area per square kilometer (km) data were obtained from the US Census 2010.

Number of wells is defined as the number of wells within a specific zip code for a certain year. All data are generated from active wells. For example, if there are 3 wells in 2007 and 8 wells in 2008 for Beovu (Brolucizumab-dbll for Intravitreal Injection)- Multum zip code, then we assume that there were an additional 5 wells created between 2007 and 2008. Given the 5-year observation period, very few active wells became inactive. In addition, the actual date of inactivity could not be accurately defined.

Furthermore, it is possible that once a well becomes inactive, it could still impact the surrounding community for some period of time. Thus, for the statistical analysis, once an active well enters at any given year, we assume the well remains active for the remainder of the years. We analyzed both exposure variables (count and bayer science material because, a priori, it was unclear whether the number of wells or the density of wells would have a stronger association with health outcomes.

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